Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrixmetalloproteinases

Authors
Levin, JI Gu, YS Nelson, FC Zask, A DiJoseph, JF Sharr, MA Sung, A Jin, GX Cowling, R Chanda, P Cosmi, S Hsiao, CL Edris, W Wilhelm, J Killar, LM Skotnicki, JS
Citation
Ji. Levin et al., Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrixmetalloproteinases, BIOORG MED, 11(2), 2001, pp. 239-242
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
239 - 242
Database
ISI
SICI code
0960-894X(20010122)11:2<239:HACSHA>2.0.ZU;2-I
Abstract
Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were i nvestigated. Of these, the pyridyl analogue 2 is the most potent and select ive inhibitor of MMP-9 and MMP-13 in vitro. (C) 2001 Elsevier Science Ltd. hll rights reserved.