3-p-Toluoyl-2-[4 '-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4 '-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of beta-amyloid peptide

Authors
Allsop, D Gibson, G Martin, IK Moore, S Turnbull, S Twyman, LJ
Citation
D. Allsop et al., 3-p-Toluoyl-2-[4 '-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4 '-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of beta-amyloid peptide, BIOORG MED, 11(2), 2001, pp. 255-257
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
255 - 257
Database
ISI
SICI code
0960-894X(20010122)11:2<255:3'A2'>2.0.ZU;2-P
Abstract
The cmc and IC50 values of the beta -amyloid (A beta) aggregation inhibitor s, 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)- phenyl]-benzofuran 1, and 2-[ 4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit beta -amyloid-peptide aggregation. (C) 20 01 Elsevier Science Ltd. All rights reserved.