Citation
Kt. Huang et Cm. Sun, Liquid-phase parallel synthesis of ureas, BIOORG MED, 11(2), 2001, pp. 271-273
Citations number
22
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
271 - 273
Database
ISI
SICI code
0960-894X(20010122)11:2<271:LPSOU>2.0.ZU;2-C
Abstract
An efficient and general liquid-phase method has been developed for the syn
thesis of a piperazine containing urea library. Reactions of the polymer bo
und carbamoyl chloride with primary or secondary amines afford ureas at amb
ient temperature. Desired compounds are liberated from the polymer support
under mild conditions in high yields and high purity by simple precipitatio
n and washings. (C) 2001 Elsevier Science Ltd. All rights reserved.