A DNA fragment from Streptomyces peucetius activates biosynthesis of actinorhodin in Streptomyces lividans and daunomycin in the original strain

Authors
Rosabal, G Rodriguez, C del Sol, R Planas, S Vallin, C Malpartida, F
Citation
G. Rosabal et al., A DNA fragment from Streptomyces peucetius activates biosynthesis of actinorhodin in Streptomyces lividans and daunomycin in the original strain, BIOTECH LET, 23(4), 2001, pp. 289-293
Citations number
22
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
BIOTECHNOLOGY LETTERS
ISSN journal
01415492 → ACNP
Volume
23
Issue
4
Year of publication
2001
Pages
289 - 293
Database
ISI
SICI code
0141-5492(200102)23:4<289:ADFFSP>2.0.ZU;2-W
Abstract
A chromosomal DNA fragment from Streptomyces peucetius SGF-107 (a producer of daunomycin) which activates the biosynthesis of two polyketide antibioti cs, daunomycin and actinorhodin, has been cloned and sequenced. Partial DNA sequencing of the activating fragment revealed the presence of two open re ading frames whose deduced products exhibit similarities with that of other known transcriptional regulators of the MarR and ArsR family, respectively .