T. Parkkali et al., Tetravalent meningococcal polysaccharide vaccine is immunogenic in adult allogeneic BMT recipients, BONE MAR TR, 27(1), 2001, pp. 79-84
Citations number
42
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Forty-four adult BMT recipients transplanted from an HLA-identical sibling
donor were randomized to receive meningococcal polysaccharide (Men PS) vacc
ine either 8 (early group; 22 patients) or 20 (late group; 22 patients) mon
ths after BMT. The geometric mean concentrations (GMC) of antibodies to ser
ogroup A Neisseria meningitidis (Men A) and serogroup C Neisseria meningiti
dis (Men C), determined by an EIA method, decreased during the first 6 mont
hs after BMT but remained at a stable level thereafter. Before vaccination
the GMCs of anti-Men A were 1.53 mug/ml and 1.61 mug/ml, but 1 month after
vaccination they were significantly higher, 3.46 mug/ml and 6.39 mug/ml, in
the early and late groups. The GMCs of anti-Men C increased from 0.37 mug/
ml and 0.44 mug/ml before vaccination to 3.31 mug/ml and 4.62 mug/ml at 1 m
onth after vaccination in the early and late groups, respectively. By 6 mon
ths after vaccination the GMCs of Men antibodies had decreased to levels of
about 50% of those measured at I month after vaccination. Two-fold respons
es to Men A PS were seen in 52% and 74% and to Men C PS in 76% and 89% of t
he BMT recipients in the early and late groups, respectively. Chronic GVHD
had no influence on the vaccination response. In the present study, Men PS
vaccine induced good and equal antibody responses to Men A and Men C PSs in
allogeneic BMT recipients regardless of timing after BMT, Vaccination agai
nst Neisseria meningitidis should be considered, especially in the event of
travelling or military service greater than or equal to8 months after BMT.