Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice
Ps. Carlton et al., Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumorigenesis in strain A/J mice, CANCER LETT, 159(2), 2000, pp. 113-117
In the present study, we examined the ability of lyophilized strawberries i
n the diet to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-
and benzo[a]pyrene (B[a]P)-induced lung tumorigenesis in the A/J mouse. Gr
oups of 20 mice were administered purified AIN-76A diet containing 10% lyop
hilized strawberries 1 week before carcinogen dosing, and for the duration
of the study. NNK was administered by i.p. injection in five. 0.414 mg dose
s. B[a]P was administered by gavage in five, 0.2 mg doses. At 20 weeks, the
re were no significant differences in tumor incidence or tumor multiplicity
between the NNK + 10% lyophilized strawberry group and the NNK control gro
up. Similarly, at 13 weeks, there were no differences in tumorigenesis betw
een the B[a]P + 10% lyophilized strawberry group and the B[a]P control grou
p. Therefore, lyophilized strawberries at 10% in the diet failed to inhibit
NNK- and B[a]P-induced mouse lung tumorigenesis. (C) 2000 Elsevier Science
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