Cytotoxicity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line

Authors
Fukushima, M Fukamiya, N Okano, M Nehira, T Tagahara, K Zhang, SX Zhang, DC Tachibana, Y Bastow, KF Lee, KH
Citation
M. Fukushima et al., Cytotoxicity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line, CANCER LETT, 158(2), 2000, pp. 151-154
Citations number
17
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
158
Issue
2
Year of publication
2000
Pages
151 - 154
Database
ISI
SICI code
0304-3835(20001001)158:2<151:CONTDF>2.0.ZU;2-6
Abstract
Seven taxane diterpenes were isolated from the EtOH extract of the aerial p arts of Taxus chinensis. and evaluated for cytotoxicity against nine human cell lines, including a beta -tublin mutant resistant to paclitaxel. Compou nd 2 a non-alkaloid-type taxane diterpene, showed significant cytotoxicity in most cell lines, and notably, equipotent against both parental and beta -tubiin mutant tumor cell lines. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.