Correlation of telomere lengths in normal and cancers tissue in the large bowel

Authors
Nakamura, K Furugori, E Esaki, Y Arai, T Sawabe, M Okayasu, I Fujiwara, M Kammori, M Mafune, K Kato, M Oshimura, M Sasajima, K Takubo, K
Citation
K. Nakamura et al., Correlation of telomere lengths in normal and cancers tissue in the large bowel, CANCER LETT, 158(2), 2000, pp. 179-184
Citations number
23
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
158
Issue
2
Year of publication
2000
Pages
179 - 184
Database
ISI
SICI code
0304-3835(20001001)158:2<179:COTLIN>2.0.ZU;2-I
Abstract
The hypothesis that telomeres in colorectal cancer cells exhibit age-relate d shortening, as in normal cells of the colorectal epithelium, was tested w ith samples of non-cancerous mucosa and cancer tissue from 124 patients (ag ed 29-97 years). Shortening with aging could be demonstrated for both norma l and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year. respectively. Straight, essentially parallel. lines were obtained for the two cases. normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level. (C) 2000 Elsevier Science Ireland Ltd. All r ights reserved.