Expression of translationally controlled tumor protein mRNA in human coloncancer

The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TC TP mRNA using a panel of normal human tissues. We also investigated the cel l-cycle-dependent expression of the TCTP mRNA using synchronized cultures o f Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon ca rcinoma cell lines and their tumors xenografted in a nude mouse was studied . Our data imply that the TCTP is a housekeeping gene and that its deregula tion may be involved in the tumor development of colon carcinoma. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.