H. Takei et al., Effects of angiogenesis inhibitor TNP-470 on tamoxifen-stimulated MCF-7 breast tumors in nude mice, CANCER LETT, 155(2), 2000, pp. 129-135
The antitumor effect of TNP-470, antiangiogenic drug, was analyzed in the t
amoxifen-stimulated MT-2 tumors inoculated in the athymic nude mice. TNP-47
0 was injected subcutaneously at a dose of 30 mg/kg body weight twice a wee
k to mice which were randomized into three treatments: control (sham treatm
ent), tamoxifen alone, and tamoxifen plus TNP-470. TNP-470 inhibited the gr
owth of the tamoxifen-stimulated MT2 tumors without any major side effects
or significant weight loss compared with tamoxifen-treated mice alone. The
mean tumor area of the mice treated with tamoxifen plus TNP-470 was reduced
50% to those treated with tamoxifen alone. TNP-470 was shown to inhibit tu
mor neovascularization and to increase incidence of apoptosis in tumor cell
s. TNP-470 did not affect tamoxifen metabolism of the mice. In conclusion,
TNP-470 could be evaluated clinically in patients with tamoxifen failure. (
C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.