Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis

In the course of our continuing search for novel cancer chemopreventive age nts from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1 ), was obtained from the leaves of Eucalyptus grandis as an active constitu ent. EG-1 exhibited the remarkable inhibitory effect on two-stage carcinoge nesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene ( DMBA) as an initiator and fumonisin-B1, which has been known as one of myco toxins produced by Fusarium monifliforme, as a promoter. Further, EG-1 exhi bited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumor using 4-nitroquinoline-N-oxide (4-NQO) as an init iator and glycerol as a promoter. (C) 2000 Elsevier Science Ireland Ltd. Al l rights reserved.