KAI-1 is a tumor suppressor gene whose down-regulation has been shown to be
associated with the development of metastases of cancer cells, Here, we de
monstrated that KAI-1 expression was induced by activating protein kinase C
even in metastatic prostate cancer cell lines in which its expression was
significantly down-regulated, KAI-1 expression was enhanced in a dose-depen
dent manner by PMA, and its induction is at least in part due to transcript
ional activation, Pretreatment with calphostin C abrogated its induction by
PMA. Our findings may provide useful information for developing a novel dr
ug capable of inducing KAI-1 expression and thereby inhibiting metastasis,
(C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.