The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers

Authors
Cuadros, R de Garcini, EM Wandosell, F Faircloth, G Fernandez-Sousa, JM Avila, J
Citation
R. Cuadros et al., The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers, CANCER LETT, 152(1), 2000, pp. 23-29
Citations number
31
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
152
Issue
1
Year of publication
2000
Pages
23 - 29
Database
ISI
SICI code
0304-3835(20000428)152:1<23:TMCSAI>2.0.ZU;2-L
Abstract
Spisulosine is a novel antiproliferative (antitumoral) compound of marine o rigin. In this work the molecular target for this toxic agent has been anal yzed. In the presence of spisulosine, cultured cells change their morpholog y, first acquiring a fusiform morphology, and later becoming rounded withou t focal adhesions. Analysis of the cytoskeleton of treated cells indicate t he absence of actin stress fibers. (C) 2000 Elsevier Science Ireland Ltd. A ll rights reserved.