Cyclin E overexpression in transitional cell carcinoma of the bladder

We attempted to clarify the relationship between cyclin E to p27(Kip1), Ki- 67 and clinicopathologic features in transitional cell bladder carcinoma. I mmunohistochemical staining of archival tissue specimens of transitional ce ll bladder carcinoma obtained from 94 patients was performed by the labeled streptavidin-biotin-peroxidase method. Overexpression of cyclin E protein was observed in 38 of the 94 (40.4%) specimens, and was positively correlat ed with histological grade, Ki-67 LI and p27(Kip1) labeling index (LI). The se data suggest that cyclin E may be associated with aggressive tumor growt h, and may have a relationship with p27(Kip1) for the regulation of cell cy cle progression in transitional cell bladder carcinoma. (C) 2000 Elsevier S cience Ireland Ltd. All rights reserved.