Glucose-6-phosphate dehydrogenase (C-B-PD) deficiency is the most common hu
man enzymopathy. In this research, we studied two groups consisting of 30 m
ale subjects who are G-6-PD deficient and 30 normal male subjects marched w
ith the G-6-PD-deficient patients fur age. All 30 assays were performed und
er normal conditions free of any oxidative attach that may result in haemol
ytic crisis in G-6-PD-deficient subjects. The erythrocyte glucose-6-phospha
te dehydrogenase, superoxide dismutase (SOD), catalase (CAT), glutathione p
eroxidase (GSH-Px), glutathione-S-transfer ase (GST) activities, reduced gl
utathione (GSH) levels and erythrocyte and plasma thiobarbituric acid-react
ive substances (TBARS) levels were measured. All parameters in each group d
id not differ significantly except for G-6-PD levels. These data show that
G-6-PD-deficient subjects can survive in normal conditions unless they are
exposed to any oxidative stress. (C) 2001 Elsevier Science B.V. All rights
reserved.