Antioxidant capacity of G-6-PD-deficient erythrocytes

Citation
S. Bilmen et al., Antioxidant capacity of G-6-PD-deficient erythrocytes, CLIN CHIM A, 303(1-2), 2001, pp. 83-86
Citations number
21
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
CLINICA CHIMICA ACTA
ISSN journal
00098981 → ACNP
Volume
303
Issue
1-2
Year of publication
2001
Pages
83 - 86
Database
ISI
SICI code
0009-8981(200101)303:1-2<83:ACOGE>2.0.ZU;2-T
Abstract
Glucose-6-phosphate dehydrogenase (C-B-PD) deficiency is the most common hu man enzymopathy. In this research, we studied two groups consisting of 30 m ale subjects who are G-6-PD deficient and 30 normal male subjects marched w ith the G-6-PD-deficient patients fur age. All 30 assays were performed und er normal conditions free of any oxidative attach that may result in haemol ytic crisis in G-6-PD-deficient subjects. The erythrocyte glucose-6-phospha te dehydrogenase, superoxide dismutase (SOD), catalase (CAT), glutathione p eroxidase (GSH-Px), glutathione-S-transfer ase (GST) activities, reduced gl utathione (GSH) levels and erythrocyte and plasma thiobarbituric acid-react ive substances (TBARS) levels were measured. All parameters in each group d id not differ significantly except for G-6-PD levels. These data show that G-6-PD-deficient subjects can survive in normal conditions unless they are exposed to any oxidative stress. (C) 2001 Elsevier Science B.V. All rights reserved.