Cryofibrinogenaemia with a good response to stanozolol

We report a 63-year-old patient with an IgA-kappa multiple myeloma in compl ete remission who developed necrotic lesions on both ears and papular, purp uric lesions on his legs and cheeks. Initial differential diagnosis include d perniosis and skin necrosis secondary to interferon treatment but subsequ ent investigation revealed cryofibrinogenaemia as the underlying cause. Sta nozolol therapy, 2 mg/12 h, achieved a complete clearance of the skin lesio ns. Cryofibrinogenaemia is a disease which can be under-diagnosed unless it is considered in the work-up of a patient with thrombotic skin lesions. St anozolol is useful as first line therapy for this disorder.