An 8-year-old patient with severe recurrent respiratory papillomatosis and
pulmonary spread was treated by systemic administration of cidofovir in ass
ociation with laser treatment for tracheal lesions. Complete disappearance
of the lesions in the pharynx and larynx and a significant yet incomplete r
egression in the bronchi and lung parenchyma were observed without deleteri
ous side effects. This is the first case report of systemic use of cidofovi
r to treat recurrent respiratory papillomatosis.