Neurological symptoms in patients whose cerebrospinal fluid is culture- and/or polymerase chain reaction-positive for Mycoplasma pneumoniae

We describe 13 patients with neurological signs and symptoms associated wit h Mycoplasma pneumoniae infection. M. pneumoniae was isolated from the cere brospinal fluid (CSF) of 9 patients: 5 with meningoencephalitis, 2 with men ingitis, and 1 with cerebrovascular infarction. One patient had headache an d difficulties with concentration and thinking for 1 month after the acute infection. M. pneumoniae was detected, by means of PCR, in the CSF of 4 pat ients with negative culture results. Two had epileptic seizures, 1 had blur red vision as a consequence of edema of the optic disk, and 1 had periphera l nerve neuropathy.