Studies on Rana tigerina skin collagen

The current paper pertains to the study of frog skin, more specifically Ran a tigerina skin collagen. which is a major extracellular matrix protein kno wn to play an important role in the wound-healing process. This study revea led interesting differences in the frog skin collagen when compared to the hitherto known vertebrate collagens. This could probably be attributed to t he position of the amphibians in the vertebrate hierarchy. Therefore, detai led investigations on the various physico-chemical properties, such as reco nstitution, redissolution, viscosity and denaturation were carried out. The study confirms the structural relationship of collagen to habitat and func tion. (C) 2001 Elsevier Science Inc. All rights reserved.