TRANSFORMING-GROWTH-FACTOR ALPHA-IMMUNOREACTIVITY IN NEURAL TISSUES OF THE RAT STOMACH

Authors
HOFFMANN P ZEEH JM LAKSHMANAN J LIU L COORAY D BARAJAS L EYSSELEIN VE
Citation
P. Hoffmann et al., TRANSFORMING-GROWTH-FACTOR ALPHA-IMMUNOREACTIVITY IN NEURAL TISSUES OF THE RAT STOMACH, Regulatory peptides, 69(3), 1997, pp. 121-125
Citations number
26
Categorie Soggetti
Endocrynology & Metabolism",Physiology
Journal title
Regulatory peptides → ACNP
ISSN journal
01670115
Volume
69
Issue
3
Year of publication
1997
Pages
121 - 125
Database
ISI
SICI code
0167-0115(1997)69:3<121:TAINTO>2.0.ZU;2-G
Abstract
We report TGF alpha immunoreactivity in neurons of the myenteric plexu s and in nerve fibers in the muscle and submucosal layers of the rat s tomach. Association of TGF alpha staining nerve fibers to vessels and smooth muscle cells gives morphological evidence that EGF/TGF alpha's actions to increase mucosal blood flow and gastric motility may be med iated by TGF alpha derived from neural structures. These data suggest that TGF alpha plays a role in the neural control of the gastric funct ion. (C) 1997 Elsevier Science B.V. All rights reserved.