Cell-cycle-dependent translational control

Authors
Pyronnet, S Sonenberg, N
Citation
S. Pyronnet et N. Sonenberg, Cell-cycle-dependent translational control, CUR OP GEN, 11(1), 2001, pp. 13-18
Citations number
59
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
13 - 18
Database
ISI
SICI code
0959-437X(200102)11:1<13:CTC>2.0.ZU;2-U
Abstract
Control of translation in eukaryotes occurs mainly at the initiation step. Translation rates in mammals are robust in the G(1) phase of the cell cycle but are low during mitosis. These changes correlate with the activity of s everal canonical translation initiation factors, which is modulated during the cell cycle to regulate translation.