Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Authors
Labib, K Diffley, JF
Citation
K. Labib et Jf. Diffley, Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?, CUR OP GEN, 11(1), 2001, pp. 64-70
Citations number
65
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
64 - 70
Database
ISI
SICI code
0959-437X(200102)11:1<64:ITMCTE>2.0.ZU;2-9
Abstract
The MCM2-7 complex is essential for both the initiation and elongation phas es of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other D NA helicases have also been implicated in the replication of eukaryotic chr omosomes.