Mitotic checkpoints: from yeast to cancer

Authors
Wassmann, K Benezra, R
Citation
K. Wassmann et R. Benezra, Mitotic checkpoints: from yeast to cancer, CUR OP GEN, 11(1), 2001, pp. 83-90
Citations number
56
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
11
Issue
1
Year of publication
2001
Pages
83 - 90
Database
ISI
SICI code
0959-437X(200102)11:1<83:MCFYTC>2.0.ZU;2-Z
Abstract
Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to res ult in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.