Effects of a single bout of exercise and exercise training on steroid levels in middle-aged type 2 diabetic men: Relationship to abdominal adipose tissue distribution and metabolic status

Lower androgen levels have been suggested to be associated with type 2 diab etes and central obesity and are probably involved into the development of atherosclerosis. The present study investigates the effect of acute and chr onic exercise on Dehydroepiandrosterone (DHEA) levels in relation to abdomi nal fat distribution and metabolic status in type 2 diabetes. Twenty weight -stable, middle-aged males with type 2 diabetes were enrolled in the study and participated in a submaximal (VO2 peak) and moderate (50% VO2 peak) exe rcise bout. The subjects were randomly assigned either to a trained or a co ntrol group, respectively. Physical training consisted of an 8 week program of aerobic exercise (75% VO2 peak, 45 min), twice a week and intermittent exercise, once a week, on a bicycle ergometer. Acute exercise significantly increased DHEA and Testosterone (T) levels. Physical training increased VO 2 peak (42%, p<0.001), insulin sensitivity index (K-ITT) (57.5%, p<0.02), a nd basal DHEA levels (36%, p<0.05), and decreased HbA1c (29%, p<0.001), vis ceral adipose tissue (VAT) (44%, p<0.01) and subcutaneous adipose tissue (S AT) levels (18%, p<0.01). Body weight, BMI and insulin, T levels were not m odified. Changes in DHEA levels were not correlated with changes in insulin sensitivity and abdominal fat distribution. In conclusion, exercise traini ng favourably affects DHEA levels independently of improvements of metaboli c status and abdominal fat distribution in patients with type 2 diabetes.