Langerhans cell histiocytosis (LCH) is a disease of unknown etiology charac
terized by a proliferation of histiocytic cells resembling the integumentar
y cells bearing the name of Langerhans cells. LCH can be unifocal or multif
ocal, with one- or many-organ involvement. We present a case of LCH diagnos
ed in the cerebrospinal fluid of a patient with generalized lymphadenopathy
and central nervous system involvement. (C) 2001 Wiley-Liss, Inc.