A girl with severe fistulizing Crohn's disease

We report the case of a girl with a severe perianal fistulizing Crohn's dis ease who during intravenous infusion of cyclosporine developed headache, ge neral seizures and cortical blindness. Head magnetic resonance imaging show ed spread, cortical-subcortical nonenhancing signal changes. Full neurologi cal recovery was achieved in 24 hours. Cyclosporine was stopped and a singl e dose of infliximab was infused with rapid improvement of the fistula that at 7 months' follow-up is still closed.