The etiology of respiratory failure associated with Stevens-Johnson sy
ndrome may be multifactorial, including upper airway involvement, pneu
mothorax/pneumomediastinum, and direct involvement of the respiratory
mucosa, Respiratory failure from direct involvement of the respiratory
mucosa is relatively uncommon, We describe a 9-year-old boy who had r
espiratory failure associated with Mycoplasma pneumoniae-induced Steve
ns-Johnson syndrome, Bronchoscopic examination of the airways revealed
sloughed mucosa, ulcerative lesions, and inspissated secretions indic
ative of lower airway involvement with Stevens-Johnson syndrome, Altho
ugh the mainstay of therapy is supportive care with controlled ventila
tion, rigid bronchoscopy with bronchoalveolar lavage to clear the airw
ays of the debris was an invaluable adjunct to this patient's care.