THE MODULATION OF THE ACTION OF ISOFORMS OF NITRIC-OXIDE SYNTHASE

The recent patent literature covering the modulation of action of the various isoforms of nitric oxide synthase (NOS) is reviewed. Mammalian biological systems in which nitric oxide (NO) has been shown to be in volved are summarised in order to give background to specific patent c laims. Claims are generally for therapy of various inflammatory states and for therapy of a number of CNS indications. Emphasis is placed on inhibitors of the several isoforms, since the patent literature is mo st extensive in this area. Patents are covered by structural class, wi th amino acids and various classes of heterocycles being the most comm on types of claimed compounds. Patent applications covering other aspe cts of control of NO concentrations in mammals are very briefly review ed, although they fall outside of the scope of NOS per se. These inclu de agents that release NO in situ, and agents that scavenge or sequest er NO.