Nj. Gorelick et Jc. Mirsalis, A STRATEGY FOR THE APPLICATION OF TRANSGENIC RODENT MUTAGENESIS ASSAYS, Environmental and molecular mutagenesis, 28(4), 1996, pp. 434-442
The past several years have seen an enormous increase in the developme
nt and use of transgenic animal models to measure mutations in specifi
c inserted reporter genes. These systems provide gene mutation data in
vivo in a wide range of relevant tissues. Numerous laboratories are n
ow using these systems with consistent results. This paper describes t
he unique niche that transgenic mutagenesis systems can fill in produc
t development and registration strategies. In addition io tissue-speci
fic mechanistic studies, transgenic assays are available to follow up
mutagenic effects demonstrated in Salmonella, Escherichia coil, mouse
lymphoma (L5 178Y) cells, or other in vitro systems. (C) 1996 Wiley-Li
ss, Inc.