N. Horii et al., Impact of neoadjuvant chemotherapy on Ki-67 and PCNA labeling indices for esophageal squamous cell carcinomas, INT J RAD O, 49(2), 2001, pp. 527-532
Citations number
29
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Purpose: The effects of neoadjuvant chemotherapy (CT) on Ki-67 and prolifer
ating cell nuclear antigen (PCNA) labeling index (LI) were analyzed, using
biopsy and surgical specimens of esophageal cancer,
Method and Materials: Immunohistochemical staining for Ki-67 and PCNA was p
erformed for biopsy and surgical specimens of 35 patients with esophageal s
quamous cell carcinoma. Seventeen patients were treated with neoadjuvant CT
(CT group), while no preoperative treatment was performed for tee remainin
g 18 patients (control group). As neoadjuvant CT, cisplatin of 50 mg/body/w
eek was administered 2-5 times (100-250 mg in total) until 7-10 days before
subtotal esophagectomy,
Result: Significant correlation between the LIs of biopsy and surgical spec
imens was observed for the control group (p = 0.006 for Ki-67 and p = 0.005
for PCNA), although both LIs of surgical specimens were significantly high
er than those of biopsy specimens (p < 0,05), However, no significant corre
lation between LIs of biopsy specimens and those of surgical specimens was
observed for the CT group. In addition, the LIs of the surgical specimens o
f the CT group were significantly lower than the LIs of the control group (
p < 0.005 for Ki-67 and p < 0.05 for PCNA). Significant decrease in Ki-67 L
I after neoadjuvant CT was noted especially for well or moderately differen
tiated squamous cell carcinomas and/or tumors treated with high-dose cispla
tin (150-250 mg).
Conclusion: Significant correlation of Ki-67 and PCNA LIs between biopsy an
d surgical specimens was demonstrated for the control group. Neoadjuvant CT
decreased the percentage of cycling and proliferative tumor cells of esoph
ageal cancer. (C) 2001 Elsevier Science Inc.