CYP19 gene polymorphism in endometrial cancer patients

Purpose: Initiation/promotion of endometrial cancer is known to be associat ed with estrogenic influence. Therefore, it is possible that some allelic p olymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility. Methods: Here, we compare d CYP19 (aromatase) gene polymorphism in 85 endometrial cancer patients and in 110 non-affected women. Results: The genotypes containing the longest a lleles (A6 and A7) of CYP19 were found to be over-represented in patients a s compared to controls. In addition, these genotypes demonstrated a tendenc y to be associated with increased concentrations of estradiol and testoster one in postmenopausal patients. Conclusions: Thus, CYP19 poly, morphism mig ht be one of the genetic risk factors for endometrial cancer development.