Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient

The authors report a case of probable serotonin syndrome caused by the coad ministration of sertraline and oxycodone. A 34 year-old male patient experi enced visual hallucinations and severe tremor after dramatically increasing his dosage of oxycodone while on stable amounts of sertraline and cyclospo rin. Discontinuation of cyclosporin did not result in resolution of his sym ptoms. Consideration of a possible sertraline-oxycodone interaction led to withholding sertraline, which resulted in symptom resolution. Serotonin syn drome has been noted with sertraline in combination with other drugs, but t his is the first report in combination with a narcotic analgesic. Possible pharmacological mechanisms are discussed. in complicated patients that are taking multiple medications, physicians should be aware of this possible in teraction to avoid delay in the diagnosis of serotonin syndrome. (C) 2001 t he American College of Clinical Pharmacology.