Fluorinated ketene dithioacetals 6. Synthesis of alpha-trifluoromethyl-gamma-lactams from bis(ethylsulfanyl) (tetrafluoroethylidene)methane

Authors
Henin, B Huot, JF Portella, C
Citation
B. Henin et al., Fluorinated ketene dithioacetals 6. Synthesis of alpha-trifluoromethyl-gamma-lactams from bis(ethylsulfanyl) (tetrafluoroethylidene)methane, J FLUORINE, 107(2), 2001, pp. 281-283
Citations number
13
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
107
Issue
2
Year of publication
2001
Pages
281 - 283
Database
ISI
SICI code
0022-1139(200102)107:2<281:FKD6SO>2.0.ZU;2-W
Abstract
A method is proposed for the synthesis of alpha -trifluoromethyl-gamma -lac tams (3-trifluoromethyl pyrrolidin-2-ones) by reductive amination of a gamm a -keto-alpha -trifluoromethyl thiol ester. The latter is prepared in high yield from the perfluoroketene dithioacetal obtained from perfluoropropanal hydrate. (C) 2001 Elsevier Science B.V. All rights reserved.