Highly fluorinated amphiphiles as drug and gene carrier and delivery systems

A shea review on fluorinated liposomes made from highly fluorinated double- chain phospho- or glyco-lipids as well as fluorinated lipoplexes, e.g. comp lexes made from highly fluorinated polycationic lipospermines and a gene, i s presented. These systems display a number of interesting physico-chemical and biological properties which make them very attractive alternatives as drug or gene carrying, targeting and delivering devices. The properties of the fluorinated liposomes that are discussed include liposome formation and shelf-stability, membrane structure, thermotropism and permeability, encap sulation, release and stability in various media (serum, detergents), bioav ailability and biodistribution, anti-MN activity. The properties of the flu orinated lipoplexes that are reported include lipoplex formation, stability , in vitro cell transfection in the presence of serum or of bile. (C) 2001 Elsevier Science B.V. All rights reserved.