Synthesis of 4,5-difluoroimidazole

Authors
Dolensky, B Takeuchi, Y Cohen, LA Kirk, KL
Citation
B. Dolensky et al., Synthesis of 4,5-difluoroimidazole, J FLUORINE, 107(1), 2001, pp. 147-148
Citations number
3
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
107
Issue
1
Year of publication
2001
Pages
147 - 148
Database
ISI
SICI code
0022-1139(200101)107:1<147:SO4>2.0.ZU;2-V
Abstract
5-Fluoroimidazole-4-carboxylic acid ethyl eater was converted to the corres ponding hydrazide. Oxidation of the hydrazide to the carbonyl azide and Cur tius rearrangement in t-butyl alcohol produced 4-t-butyloxycarbonylamino-5- fluoroimidazole. Dissolution of the t-butyl carbamate in 50% HBF4, in situ diazotation of the resulting amine, and irradiation produced the target com pound. (C) 2001 Elsevier Science B.V. All rights reserved.