Experimental and theoretical structural study of 2-pyridyl- and 4-hydroxyphenyl-1,4-dihydropyridine derivatives

Authors
de Armas, HN Blaton, N Peeters, OM De Ranter, C Suarez, M Rolando, E Verdecia, Y Ochoa, E Martin, N Quinteiro, M Seoane, C Soto, JL
Citation
Hn. De Armas et al., Experimental and theoretical structural study of 2-pyridyl- and 4-hydroxyphenyl-1,4-dihydropyridine derivatives, J HETERO CH, 37(6), 2000, pp. 1575-1581
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022152X → ACNP
Volume
37
Issue
6
Year of publication
2000
Pages
1575 - 1581
Database
ISI
SICI code
0022-152X(200011/12)37:6<1575:EATSSO>2.0.ZU;2-Z
Abstract
A series of substituted 1,4-dihydropyridines (1,4-DHPs) has been synthesise d following the well-known Hantzsch's procedure for symmetrical 1,4-DHP. Th e structures of these compounds have been thoroughly studied by X-ray cryst allographic analysis and semiempirical (AMI) calculations. A good agreement is found between the theoretical and experimental results. In all cases, t he most stable conformation fulfils all the requirements needed for exhibit ing an antagonist calcium effect.