The synthesis of labelled forms of cipemastat

Authors
Wiltshire, HR Prior, KJ Dhesi, J Maile, G
Citation
Hr. Wiltshire et al., The synthesis of labelled forms of cipemastat, J LABEL C R, 44(2), 2001, pp. 149-164
Citations number
6
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
2
Year of publication
2001
Pages
149 - 164
Database
ISI
SICI code
0362-4803(200102)44:2<149:TSOLFO>2.0.ZU;2-G
Abstract
The development of the collagenase inhibitor, cipemastat (Ro 32-3555), requ ired the synthesis of both carbon-14 labelled and deuteriated material for the measurement of the parent drug and drug-related material in biological fluids. In addition, labelled metabolites were needed for both in vitro met abolism and analytical studies. This paper describes the synthesis of label led forms of cipemastat and its amide (Ro 32-4778) and glucuronide (Ro 32-6 414) metabolites,