Calculation of the hydrophobicity of platinum drugs

Models of the hydrophobicity of platinum drugs based on exposed surface are as of polar and nonpolar atoms are presented. For a total of 24 log P-oct d ata, the best model resulted in a standard deviation of 0.35 over a range o f more than 4 log units, with regression coefficients in broad agreement wi th previous models of log P-oct for organic molecules. This model is used t o compare log P-oct to cell uptake for five platinum drugs and hence to est ablish an exponential relation between these parameters.