Iridoid glycosides from Globularia trichosantha

A new iridoid glycoside, deacetylalpinoside (2), was isolated from the aeri al parts of Globularia trichesantha together with nine known iridoid glycos ides: catalpol, 10-O-benzoyl-catalpol, aucubin, asperuloside, deacetylasper uloside, asperulosidic acid, scandoside, geniposidic acid, and alpinoside ( 1). From the underground parts of the same plant, two new bisiridoid glycos ides, globulosides A (3) and B (4); a known iridoid glycoside, globularidin ; a lignan glycoside, liriodendrin; and seven phenylethanoid glycosides, ar enarioside, verbascoside (= acteoside), isoacteoside, crenatoside, isocrena toside, and trichosanthosides A and B, were isolated. Compounds 2-4 are new iridoids containing an 8,9 double bond representing a rare carbon skeleton . Their structures were established by spectroscopic methods.