Nodularin-Har: A new nodularin from Nodularia

Authors
Saito, K Konno, A Ishii, H Saito, H Nishida, F Abe, T Chen, CY
Citation
K. Saito et al., Nodularin-Har: A new nodularin from Nodularia, J NAT PROD, 64(1), 2001, pp. 139-141
Citations number
24
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
64
Issue
1
Year of publication
2001
Pages
139 - 141
Database
ISI
SICI code
0163-3864(200101)64:1<139:NANNFN>2.0.ZU;2-P
Abstract
A cyanobacterial hepatotoxin, nodularin-Har, having a homoarginine instead of an arginine in nodularin, was isolated from Nodularia PCC7804. The struc ture was elucidated as I on the basis of 2D NMR and FABMS. The LD50 (mouse ip) value of 1 was 70 mug/kg.