Despite reports suggesting numerous academic and social behavior deficits i
n boys with fragile X syndrome (FXS), little information is available conce
rning their actual classroom academic and social behavior. In this study, d
irect observational data were collected on the behavior of 26 elementary sc
hool-age boys with FXS during classroom academic activities in primarily se
lf-contained special education classrooms. Results indicated moderate level
s of academic engagement during periods of academic instruction, comparable
to that of their classroom peers. Classroom engagement was not related to
intrasubject variables such as severity of delay, autism status, or medicat
ion usage. A general measure of classroom quality and instruction was signi
ficantly correlated with engagement. Relatively low levels of stereotypic o
r self-injurious behavior were observed. These findings are discussed in re
lation to the existing engagement literature for school-age individuals wit
h disabilities and issues concerning syndrome specific behaviors.