The PUVA-turban as a new option of applying a dilute psoralen solution selectively to the scalp of patients with alopecia areata

Background: Alopecia areata is a burden for many patients and often resista nt, even to extensive therapy. Orally administered PUVA therapy has been sh own among numerous systemic and topical treatment modalities to be a therap eutic alternative. However., the clinical use of oral PUVA is often limited by systemic side effects. Bath-PUVA therapy offers an alternative solution because of the negligible systemic absorption of psoralen with this techni que. Through use of a "PUVA-turban" it is now possible to administer a dilu te bathwater solution containing 8-methoxypsoralen (8-MOP) to the scalp. Objective: The purpose of this study was to determine whether PUVA turban t herapy is effective in treating alopecia areata in different clinical stage s. Methods: We treated 9 patients with severe, rapidly progressing, treatment- resistant alopecia areata with PUVA-turban treatment as a modification of b ath-PUVA therapy. At each treatment session a cotton towel was soaked with a 0.0001% 8-MOP solution (1 mg/L) at 37 degreesC, wrung gently remove exces s water, and wrapped around the patient's head in a turban fashion for 20 m inutes. This was directly followed by UVA radiation. Treatment sessions wer e initially performed 3 to 4 times per week. Results: The cumulative UVA doses given over treatment periods of up to 24 weeks were 60.9 to 178.2 J/cm(2), with single doses ranging from 0.3 to 8.0 J/cm(2). After up to 10 weeks of treatment, hair regrowth could be noticed in 6 of 9 patients. Two patients did not respond to the treatment, and one patient showed only vellus hair regrowth. Conclusion: PUVA-turban therapy can be considered a useful method of admini stering a dilute psoralen solution selectively to the scalp of patients. It has been shown to be a well-tolerated and, in some patients, efficient the rapeutic alternative in the treatment of alopecia areata.