UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin

UVB irradiation is known to produce DNA damage at mutation hotspots in the p53 tumor suppressor gene, leading to the development of skin cancers. Muta tions in the PTCH tumor suppressor gene, which is known to be responsible f or the development of nevoid basal cell carcinoma syndrome, have also been identified in sporadic basal cell carcinomas (BCCs). We describe the case o f an 80-year-old welder in whom 3 novel p53 mutations, as well as UV-specif ic PTCH mutations, were detected in two BCC samples fi om sun-exposed skin. The simultaneous presence of UV-specific p53 and PTCH mutations in the sam e BCC sample has not previously been reported.