Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

Authors
Duncan, SJ Gruschow, S Williams, DH McNicholas, C Purewal, R Hajek, M Gerlitz, M Martin, S Wrigley, SK Moore, M
Citation
Sj. Duncan et al., Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp., J AM CHEM S, 123(4), 2001, pp. 554-560
Citations number
15
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN journal
00027863 → ACNP
Volume
123
Issue
4
Year of publication
2001
Pages
554 - 560
Database
ISI
SICI code
0002-7863(20010131)123:4<554:IASEOC>2.0.ZU;2-7
Abstract
Wild-type p53 plays a crucial role in the prevention of cancer. Since dysfu nction of p53 can be caused by increased levels of the protein MDM2, small molecules which antagonize the interaction between these two-proteins have- potential in cancer therapy. The discovery and structure determination of a fungal metabolite, chlorofusin, which antagonizes the p53/MDM2 interaction are reported.