Zinc status and cytokine profile in pediatric Hodgkin's disease

Studies of peripheral blood lymphocytes (PBLs) and serum from 23 children w ith Hodgkin's disease (HD) show that serum soluble interleukin-2 receptor ( sIL2R) and tumor necrosis factor (TNF)-alpha levels are closely related wit h disease status [patients with active disease (n = 23) 3552 +/- 1551 IU/mL , in remission (n = 23) 1466 +/- 613.7 IU/mL vs. control group(n = 10) 557 +/- 125 IU/mL (P < 0.001); patients with active disease (n = 23) 946 +/- 43 3 pg/mL, in remission (n = 11) 256 +/- 110 pg/mL vs. control group (n = 10) 35 +/- 16.7 pg/mL (P < 0.001) respecticely], but no correlation between se rum sIL2R levels and PBL CD25 expression and TNF-alpha levels. Some previou sly recognized clinical and laboratory variables such as histology, clinica l stage, ESR, blood, and hair zinc levels were analyzed to evaluate whether the levels of serum sIL2R and TNF-alpha were associated with clinical and pathologic parameters of HD. J. Trace Elem. Exp. Med. 14:25-30, 2001. (C) 2 001 Wiley-Liss, Inc.