SUPPRESSION OF TUMOR-GROWTH BY THE 3' UNTRANSLATED REGION OF MEL-18 IN 3Y1-CELLS TRANSFORMED BY THE E6-GENES AND E7-GENES OF HUMAN PAPILLOMAVIRUS TYPE-18

Authors
ISHIWATARI H NAKANISHI K KONDOH G HAYASAKA N LI Q YAMASHITA A INOUE H HAKURA A
Citation
H. Ishiwatari et al., SUPPRESSION OF TUMOR-GROWTH BY THE 3' UNTRANSLATED REGION OF MEL-18 IN 3Y1-CELLS TRANSFORMED BY THE E6-GENES AND E7-GENES OF HUMAN PAPILLOMAVIRUS TYPE-18, Cancer letters, 117(1), 1997, pp. 57-65
Citations number
36
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
117
Issue
1
Year of publication
1997
Pages
57 - 65
Database
ISI
SICI code
0304-3835(1997)117:1<57:SOTBT3>2.0.ZU;2-Y
Abstract
By introducing a cDNA library derived from rat embryonic fibroblast ce lls, we isolated several morphologically flat revertants of rat 3Y1 ce lls transformed by the E6 and E7 genes of human papillomavirus type 18 (HPV18). From one of the revertants, we recovered a 0.2-kb cDNA, N56, that suppresses the tumor growth of the transformed 3Y1 cells irrespe ctive of the expression of the E6 and E7 genes. The nucleotide sequenc e of the cDNA was shown to be identical to that of the 3' untranslated region of a putative mammalian polycomb group gene, mel-18. (C) 1997 Elsevier Science Ireland Ltd.