Genomic strategies to identify mammalian regulatory sequences

With the continuing accomplishments of the human genome project, high-throu ghput / strategies to identify DNA sequences that are important in mammalia n gene regulation are becoming increasingly feasible. In contrast to the hi storic, labour-intensive, wet-laboratory methods for identifying regulatory sequences, many modern approaches are heavily focused. on the computationa l analysis of large genomic data sets. Data from inter-species genomic sequ ence comparisons and genome-wide expression profiling, integrated with vari ous computational tools, are poised to contribute to the decoding of genomi c sequence and to the identification of those sequences that orchestrate ge ne regulation. in this review, we highlight several genomic approaches that are being used to identify regulatory sequences in mammalian genomes.