Intra-ischemic hypothermia attenuates intercellular adhesion molecule-1 (ICAM-1) and migration of neutrophil

Adhesion of neutrophil to the endothelium and subsequent transmigration has been reported to contribute to progression of focal ischemia. Hypothermia has been known to attenuate ischemic insult through Various mechanisms of a ction. The authors evaluated the effect of hypothermia on expression of int ercellular adhesion molecule-1 (ICAM-1) protein and on transmigration of ne utrophil with immunohistochemical method. Transient focal ischemia model in rats was employed, and animals received 2 h of either normothermic or hypo thermic ischemia. To confirm the effectiveness of hypothermia on neuroprote ction, cortical infarct area was compared between the two groups. Our resul ts demonstrated that hypothermia reduced both the number of microvessels ex pressing ICAM-1 and that of neutrophils migrating into ischemic tissue. Com parison of cortical infarct area showed persistent protective effect This s tudy indicates that reduction of ICAM-1 expression and subsequent reduction of migrating neutrophil in hypothermia can contribute to attenuation of is chemic damage.