Definite segregation of cortical neurons projecting to the dorsal column nuclei in the rat

The dorsal column nuclei (DCN) receive a substantial contingent of projecti ons that arise from a number of somatosensory and motor cortical areas. We investigated the spatial organization of these projections in the rat by pl acing small deposits of two retrograde fluorescent tracers in adjacent foci within the DCN; Single-labeled neurons were abundant in layer V of the pri mary somatosensory (SI) and motor areas, and in the posterior parietal cort ex. More sparse labeling was found in the medial agranular cortex (or MII), and the second somatosensory area. A somatotopic-like arrangement of these neurons was more clearly noticed in the granular zones of SI. Double-label ed neurons were very uncommon, and appeared at border regions where single- labeled cells intermingled. The segregation of these projections supports s ome differential modulatory effects that the cortex exerts on the somatosen sory processing that takes place in the DCN. NeuroReport 12:413-416 (C) 200 1 Lippincott Williams & Wilkins.