The reverse transcriptase model of somatic hypermutation

Authors
Steele, EJ Blanden, RV
Citation
Ej. Steele et Rv. Blanden, The reverse transcriptase model of somatic hypermutation, PHI T ROY B, 356(1405), 2001, pp. 61-66
Citations number
46
Categorie Soggetti
Multidisciplinary,"Experimental Biology
Journal title
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
ISSN journal
09628436 → ACNP
Volume
356
Issue
1405
Year of publication
2001
Pages
61 - 66
Database
ISI
SICI code
0962-8436(20010129)356:1405<61:TRTMOS>2.0.ZU;2-W
Abstract
The evidence supporting the reverse transcriptase model of somatic hypermut ation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermut ation pattern in the human BCL-6 gene can be interpreted in terms of the re verse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.